What is this database?

Not all medical trials are published in medical journals. There are several factors affecting the chance of publication of a trial in medical journals, e.g. publication bias. A systematic reviewer should not limit ones-self to published sources of evidence. Registries listed below, provide informationabout on-going and completed medical trials held by their center or others, and are worth searching into, in appropriate cases.

We have collectedthe records of this database, through online searches. There is no doubt the list is not complete. If you are aware of such web sites, that are not listed here, please don't hesitate to contact us.

Name of the registry	More comments about the registry
Acurian	Acurian is a leading provider of clinical trial patient and investigator recruitment solutions for the pharmaceutical and biotechnology industries. Through customized data mining of proprietary databases, Acurian is able to identify, contact, prescreen, and refer interested patients, as well as profile and recruit experienced investigators, quickly and affordably. Since 1998, Acurian has helped accelerate more than 100 clinical trials for over 30 pharmaceutical and biotechnology companies, including 8 of the top 10 pharmaceutical companies in the world. Acurian 's investors include Euclid SR Partners, ProQuest Investments, JP Morgan Partners, CDP Capital Technology Ventures, Flatiron Partners & Merck Capital Ventures.
AIDSinfo	AIDSinfo is a U.S. Department of Health and Human Services (DHHS) project providing information on HIV/AIDS clinical trials and treatment. It is the result of merging two previous DHHS projects: The AIDS Clinical Trials Information Service (ACTIS) and the HIV/AIDS Treatment Information Service (ATIS).
Alquest	Provides efficient, cost effective Contract Research Organization (CRO) services to the global medical device community. Alquest is a full-service Contract Research Organization offering regulatory, clinical and compliance services for medical devices, biologics, and combination products. It provides client with staff, clinical recourses or managers to do clinical trials on their medical devices. There is also a list of presentations on clinical trials (how to perform, basis...) and the slides are available.
American College of Rheumatology	The American College of Rheumatology (ACR) is a well-organized association of rheumatologists, and related professionals which provides its members with education, meetings, symposiums,.... The site includes links to informative clinical trial providers and also publications.
American Society of Breast Surgeons	The American Society of Breast Surgeons , with more than 1600 surgeon members in United States, provides its members with opportunities for research, to promote breast surgery techniques and standards. The site includes summaries about some active clinical trials and also links for sites, which provide clinical trials.
Australian Crohn's and Colitis association	ACCA will generate and foster awareness and educational programs targeted at persons diagnosed with IBD (inflammatory bowel disease), their families, health professionals and the general public. Where appropriate, ACCA will publicly and financially support both pure and clinical research into the cause of, and the cure for inflammatory bowel disease.
Breast cancer clinical trials	An important contribution to medical research has been achieved by setting up a National Clinical Trials Registry. This Registry is currently focusing on cancer trials.
California Pacific Medical Center	Listing of selected clinical trials that have been approved by their Institutional Review Board.
Cancer research UK	The aim of the CancerHelp UK clinical trials database is to provide patients with information about clinical trials that they may be able to take part in. It is limited to UK trials, or international trials held on by organizations that have a UK center. The clinical trials registry was launched on 2000.
Cancer.gov	The NCI/PDQ clinical trials registry is limited to studies of cancer and cancer-related conditions. The clinical trials extend in time from 1978 to the present. Approximately 80% of the trials in this registry are accruing patients only at sites in the United States; approximately 20% are accruing patients at sites in either Canada or Europe.
Cardiosource	Cardiosource is a unique collaboration between the American College of Cardiology Foundation and Elsevier. It has produced the most comprehensive online cardiovascular information and educational resource available.
Center Watch	CenterWatch is a Boston-based publishing and information services company. Founded in 1994, CenterWatch strives to be a leader in print and internet - based information services focusing on the clinical trials industry.
Clinical Research Center	The CRC was conceived in 1997 and has been operational since August 2000. CRC functions as the clinical research arm of the Ministry of Health Malaysia, and is located in Kuala Lumpur Hospital. It is one of several research organizations under the umbrella of the National Institutes of Health of the MOH. The others are the Institute for Medical Research (IMR), Institute of Public Health (IPH), Institute of Health Management (IHM) and the Institute of Health Promotion (IHP).
ClinicalTrials.com	CLINICALTRIALS.COMT is an Internet resource for finding clinical trials in the United States and Canada. Our site also provides thousands of local and national organizations that are associated with specific illnesses. We hope to help educate potential trial volunteers on clinical trials as well as help researchers find new participants for their research.
ClinicalTrials.gov	CLINICALTRIALS.GOV currently contains approximately 9,000 clinical studies sponsored by the National Institutes of Health, other federal agencies, and private industry. Studies listed in the database are conducted primarily in the United States and Canada, but include locations in about 90 countries.
CTN clinical trials	Canadian HIV Trials Network (CTN) is a federally funded, non-profit, national organization created to facilitate HIV/AIDS clinical trial activity in Canada. A cornerstone of the federal government's Canadian Strategy on HIV/AIDS, the Network was established in response to the needs and concerns of Canadian clinical investigators, persons living with HIV/AIDS, the pharmaceutical industry, community physicians, specialists, and laboratories. The CTN is funded by Health Canada, and jointly sponsored by The University of British Columbia and St. Paul's Hospital, Vancouver.
Current Controlled Trials	Current Controlled Trials is published by BioMed Central, an independent publishing house committed to providing immediate free access to peer reviewed biomedical research. The Current Controlled Trials web site has been developed by Current Controlled Trials Ltd , part of the Current Science Group of companies (http://sciencenow.com). The Group has its headquarters in London, UK and also has offices in Philadelphia and Tokyo.
GlaxoSmithKline Clinical Trials	This register has been developed to provide healthcare professionals and researchers with information on the company's clinical trials programs. GlaxoSmithKline recognizes the growing importance of evidence-based medicine and the needs of our customers. Decision makers, including healthcare purchasers and providers, require access to clinical trials information, thereby facilitating awareness of the full range of current research undertaken in a specific area.
MAYO Clinic	The clinical trials found by searching here include only those clinical trials that Mayo researchers have chosen to publish to the Web.
MediStudy	MediStudy.com Inc. is a privately owned, Canadian company. MediStudy.com introduces itself as the first central database of clinical trials in Canada.
MSOURCE	MSOURCE is a full-service Contract Research Organization providing a range of clinical development services to the pharmaceutical, biotechnology, and medical device industries. Provides told industries with staff, clinical services and other facilities to perform clinical trials, to approve their products.
MyhealthCANADA - The Canadian Clinical Trials Directory	No further information available at the moment.
National Cancer Institute of Canada, Clinical Trials Group	The NCIC CTG is a cooperative oncology group which carries out clinical trials in cancer therapy and supportive care across Canada and internationally. It is one of the national programs and networks of the National Cancer Institute of Canada (NCIC), and is supported by the NCIC with funds raised by the Canadian Cancer Society (CCS). The institute is located at Queen's University, Kingston Ontario.
New Jersey Cancer Trial Connect	Clinical trials on cancer treatment can be found here. It seems that the site is specially for patients, but others can also find clinical trials. Registration is needed for getting the full text, but it's free.
NHMRC clinical trials center	The National Clinical Trials Registry aims to provide a complete and comprehensive catalogue of clinical trials in which Australians are participating. The register was established in 1994 as a register of cancer trials, and expanded to include maternal/prenatal trials in 2000. Their goal is to submit a grant application to enable the register to be expanded to include all randomized clinical trials in which Australians are participating. It only registers cancer trials, being conducted in Australia. The National Clinical Trials Registry was established in 1995.
NIH Clinical Research Studies	No further information available at the moment.
NIHM	The National Institute of Mental Health (NIMH) is one of 27 components of the National Institutes of Health (NIH), the Federal government's principal biomedical and behavioral research agency. NIH is part of the U.S. Department of Health and Human Services. The NIMH mission is to reduce the burden of mental illness and behavioral disorders through research on mind, brain, and behavior.
Northeast Cognitive Rehabilitation Research Network (NCRRN)	A scientific core dedicated to fostering research on the treatment of acquired cognitive disorders, with particular emphasis on initial-stage, controlled efficacy studies. The Clinical Trials Core serves the needs of investigators who have the interest and skills to advance cognitive rehabilitation research, but who would otherwise lack the resources, especially access to subjects and trained clinical staff. The Clinical Trials Core is based at MossRehab/MRRI, and utilizes contractual arrangements with Bryn Mawr Rehab and Magee Rehab.
PsiTri	PsiTri is a freely available database on published and unpublished controlled clinical trials, reporting on treatments and interventions for a wide range of conditions within the field of mental health. Offering access to the specialized trial registers of the five mental health related Cochrane Review Groups, PsiTri is a comprehensive source of reliable, high quality research. PsiTri contains information on randomized controlled trials (RCTs) or controlled clinical trials (CCTs) only.
Rehab Trials	This registry separately categorizes clinical trials which involve rehabilitation populations, and the research protocols employed which consider the unique needs of such population. RehabTrials.org is a project of the Kessler Medical Rehabilitation Research and Education Corporation (KMRREC), in West Orange, New Jersey.
Spine-Health	Provides information about treatment of back and neck pain. Also gives information on performing clinical trials. There is a list of active industry-sponsored clinical trials on Spine.
Trials Central	TrialsCentralT provides free and confidential access to listings of clinical trials. Information about current clinical research helps support informed evidence-based decision making in healthcare.

Hojjat Salmasian, Mersedeh Rohanizadegan, Raheleh Rahimi

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